Protein kinase B (PKB/AKT) protects IDH-mutated glioma from ferroptosis via Nrf2.
Yang LiuFu-Ju ChouFengchao LangMeili ZhangHua SongWei ZhangDionne L DavisNicole J BricenoYang ZhangPatrick J CiminoKareem A ZaghloulMark R GilbertTerri S ArmstrongChunzhang YangPublished in: Clinical cancer research : an official journal of the American Association for Cancer Research (2023)
Our findings highlighted AKT/Nrf2 pathways as a potential synthetic lethality target for IDH mutated cancers.