WGCNA-Based DNA Methylation Profiling Analysis on Allopurinol-Induced Severe Cutaneous Adverse Reactions: A DNA Methylation Signature for Predisposing Drug Hypersensitivity.

Lin ChengBao SunYan XiongLei HuLichen GaoJi LiHongfu XieXiaoping ChenWei ZhangHong-Hao Zhou

Published in: Journal of personalized medicine (2022)

DNA methylation plays a vital role in allopurinol-induced SCARs. DNA methylation profiling of SJS/TEN is significantly related to autophagy and microRNAs (miRNAs).

Keyphrases

dna methylation
drug induced
genome wide
gene expression
high glucose
diabetic rats
oxidative stress
cell death
endothelial cells
electronic health record