High serum miR-421 is associated with metabolic dysregulation and inflammation in patients with metabolic syndrome.
Aécio A BragaRaul Hernandes BortolinMagda E Graciano-SaldarriagaThiago Dominguez Crespo HirataÁlvaro CerdaRenata Caroline Costa FreitasHui Tzu Lin-WangJessica Bassani BorgesJoão Italo Dias FrançaLaureane Nunes MasiRui CuriTania Cristina Pithon-CuriMarcelo Ferraz SampaioLara R CastroGisele Medeiros BastosRosario Dominguez Crespo HirataMario Hiroyuki HirataPublished in: Epigenomics (2021)
Aim: To explore the association of circulating miRNAs with adiposity, metabolic status and inflammatory biomarkers in patients with metabolic syndrome (MetS). Methods: Serum levels of 372 miRNAs were measured in patients with (n = 6) and without MetS (n = 6) by quantitative PCR array, and dysregulated miRNAs were validated in a larger cohort (MetS, n = 89; non-MetS, n = 144). Results: In the screening study, seven miRNAs were dysregulated in patients with MetS, and miR-421 remained increased in the validation study. miR-421 was associated with a high risk of MetS and insulin resistance and hypertension and correlated with glycated hemoglobin, triacylglycerols, high-sensitivity CRP, IL-6, resistin and adiponectin (p < 0.05). Conclusion: Circulating miR-421 is a potential biomarker for insulin resistance, metabolic dysregulation and inflammatory status in patients with MetS.
Keyphrases
- insulin resistance
- metabolic syndrome
- cell proliferation
- long non coding rna
- long noncoding rna
- high fat diet
- adipose tissue
- oxidative stress
- skeletal muscle
- type diabetes
- polycystic ovary syndrome
- blood pressure
- high fat diet induced
- uric acid
- high resolution
- weight loss
- cardiovascular disease
- high throughput
- single cell
- high density