Ionic liquid-mediated ethosome for transdermal delivery of insulin.

Fahmida Habib Nabila Rashedul IslamIslam Md ShimulMuhammad MoniruzzamanRie WakabayashiNoriho Kamiya Masahiro Goto

Published in: Chemical communications (Cambridge, England) (2024)

Herein, we report ethosome (ET) formulations composed of a safe amount of 1,2-dimyristoyl- sn-glycero -3-phosphatidylcholine (DMPC)-based ionic liquid with various concentrations of ethanol as a carrier for the transdermal delivery of a high molecular weight drug, insulin. The Insulin-loaded ET vesicles exhibited long-term stability compared to conventional DMPC ETs, showing significantly higher drug encapsulation efficiency and increased skin permeation ability.

Keyphrases

ionic liquid
type diabetes
room temperature
glycemic control
transcription factor
drug delivery
drug induced
soft tissue
adverse drug
adipose tissue
insulin resistance
skeletal muscle
weight loss