Metabolomics changes in brain-gut axis after unpredictable chronic mild stress.

Qiuyue XuMingchen JiangSimeng GuXunle ZhangGuangkui FengXianjun MaShijun XuErxi WuJason H HuangFushun Wang

Published in: Psychopharmacology (2022)

Coexistence of brain and gut metabolic changes in UCMS-induced depressive behavior in rats suggests a possible role of brain-gut axis in depression. This study provides insights into the neurobiology of depression.

Keyphrases

resting state
white matter
stress induced
depressive symptoms
functional connectivity
sleep quality
cerebral ischemia
mass spectrometry
bipolar disorder
multiple sclerosis
drug induced
high glucose
diabetic rats
oxidative stress
physical activity
subarachnoid hemorrhage
heat stress