Replication Stress and Consequential Instability of the Genome and Epigenome.
Pawlos P TsegayYanhao LaiYuan LiuPublished in: Molecules (Basel, Switzerland) (2019)
Cells must faithfully duplicate their DNA in the genome to pass their genetic information to the daughter cells. To maintain genomic stability and integrity, double-strand DNA has to be replicated in a strictly regulated manner, ensuring the accuracy of its copy number, integrity and epigenetic modifications. However, DNA is constantly under the attack of DNA damage, among which oxidative DNA damage is the one that most frequently occurs, and can alter the accuracy of DNA replication, integrity and epigenetic features, resulting in DNA replication stress and subsequent genome and epigenome instability. In this review, we summarize DNA damage-induced replication stress, the formation of DNA secondary structures, peculiar epigenetic modifications and cellular responses to the stress and their impact on the instability of the genome and epigenome mainly in eukaryotic cells.
Keyphrases
- dna methylation
- dna damage
- genome wide
- copy number
- induced apoptosis
- circulating tumor
- oxidative stress
- cell cycle arrest
- gene expression
- cell free
- mitochondrial dna
- dna repair
- cell death
- signaling pathway
- endoplasmic reticulum stress
- mass spectrometry
- pi k akt
- circulating tumor cells
- cell proliferation
- social media
- health information