Variation in Alanine Aminotransferase in Children with Non-Alcoholic Fatty Liver Disease.
Eduardo Castillo-LeonHeather L MorrisCheryl SchoenJacob BilhartzPatrick McKiernanTamir MilohSirish PalleMohammad Nasser KabbanyBreda MunozAndrea R MospanBryan RudolphStavra A XanthakosMiriam B Vosnull Target-Nash InvestigatorsPublished in: Children (Basel, Switzerland) (2022)
Large variability was seen in ALT among children, including many values > 250 U/L. Higher levels of ALT were associated with increased prevalence of comorbidities and more advanced stages of NAFLD. These findings support an increased need for therapeutics and disease severity assessment in children with peak ALT > 70 U/L.