MicroRNA 452 regulates IL20RA-mediated JAK1/STAT3 pathway in inflammatory colitis and colorectal cancer.

Santosh LamichhaneJi-Su MoGrinsun SharmaTae-Young ChoiSoo Cheon Chae

Published in: Inflammation research : official journal of the European Histamine Research Society ... [et al.] (2021)

Our results suggest that MIR452 regulates STAT3 through the IL20RA-mediated JAK1 pathway, but not STAT1. Overall, MIR452 acts as tumor suppressor in human CRC and in a mouse colitis model. These findings suggest that MIR452 is a promising therapeutic target in the treatment of cancer and colitis.

Keyphrases

cell proliferation
long non coding rna
long noncoding rna
rheumatoid arthritis
endothelial cells
ulcerative colitis
oxidative stress
disease activity
ankylosing spondylitis
squamous cell
squamous cell carcinoma
induced pluripotent stem cells
systemic lupus erythematosus
childhood cancer