Widespread recovery of methylation at gametic imprints in hypomethylated mouse stem cells following rescue with DNMT3A2.

Avinash ThakurSarah-Jayne MackinRachelle E IrwinKarla M O'NeillGareth PollinColum P Walsh

Published in: Epigenetics & chromatin (2016)

These results suggested (1) a vital role for DNMT3A/B in methylation maintenance at imprints, (2) that loss of DNMT1 and DNMT3A/B had equivalent effects, (3) that rescue with DNMT3A2 can restore imprints in these cells. This may provide a useful system in which to explore factors influencing imprint reprogramming.

Keyphrases

dna methylation
genome wide
stem cells
gene expression
induced apoptosis
cell cycle arrest
cell proliferation