Transnasal cooling: New prospect of selective hypothermia in acute ischemic stroke.
Xi ChenShuaili XuMing LiDi WuXun-Ming JiPublished in: Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism (2023)
Rapid and selective therapeutic hypothermia is a promising neuroprotective method for acute ischemic stroke. A recent study developed a simple but efficient technique of transnasal cooling, in which air at ambient temperature was passed through standard nasal cannula to induce evaporative cooling of the brain. Selective brain temperature decrease was achieved within 25 minutes in piglets. It is a major step forward to initiate early brain cooling. However, it is still necessary to devise a more comprehensive strategy to enhance the benefits of selective brain cooling in the era of effective reperfusion.
Keyphrases
- cerebral ischemia
- acute ischemic stroke
- resting state
- white matter
- brain injury
- cardiac arrest
- functional connectivity
- subarachnoid hemorrhage
- air pollution
- acute myocardial infarction
- intensive care unit
- particulate matter
- acute coronary syndrome
- atrial fibrillation
- obstructive sleep apnea
- respiratory failure
- percutaneous coronary intervention