EEG Source Imaging (ESI) utility in clinical practice.
Pegah KhosropanahEric Tatt-Wei HoKheng-Seang LimSi-Lei FongMinh-An Thuy LeVairavan NarayananPublished in: Biomedizinische Technik. Biomedical engineering (2020)
Epilepsy surgery is an important treatment modality for medically refractory focal epilepsy. The outcome of surgery usually depends on the localization accuracy of the epileptogenic zone (EZ) during pre-surgical evaluation. Good localization can be achieved with various electrophysiological and neuroimaging approaches. However, each approach has its own merits and limitations. Electroencephalography (EEG) Source Imaging (ESI) is an emerging model-based computational technique to localize cortical sources of electrical activity within the brain volume, three-dimensionally. ESI based pre-surgical evaluation gives an overall clinical yield of 73-91%, depending on choice of head model, inverse solution and EEG electrode density. It is a cost effective, non-invasive method which provides valuable additional information in presurgical evaluation due to its high localizing value specifically in MRI-negative cases, extra or basal temporal lobe epilepsy, multifocal lesions such as tuberous sclerosis or cases with multiple hypotheses. Unfortunately, less than 1% of surgical centers in developing countries use this method as a part of pre-surgical evaluation. This review promotes ESI as a useful clinical tool especially for patients with lesion-negative MRI to determine EZ cost-effectively with high accuracy under the optimized conditions.
Keyphrases
- ms ms
- resting state
- temporal lobe epilepsy
- functional connectivity
- minimally invasive
- magnetic resonance imaging
- working memory
- clinical practice
- high resolution
- coronary artery disease
- multiple sclerosis
- coronary artery bypass
- computed tomography
- drinking water
- social media
- mass spectrometry
- surgical site infection
- fluorescence imaging
- photodynamic therapy
- cerebral ischemia