Apolipoprotein CIII and Angiopoietin-like Protein 8 are Elevated in Lipodystrophy and Decrease after Metreleptin.

Marissa Lightbourne Anna WolskaBrent S AbelKristina I RotherMary WalterYevgeniya KushchayevaSungyoung AuhRobert D ShamburekAlan T RemaleyRanganath Muniyappa Rebecca J Brown

Published in: Journal of the Endocrine Society (2020)

Elevations in LPL inhibitors apoC-III and ANGPTL8 may contribute to hypertriglyceridemia in lipodystrophy, and may mediate reductions in circulating and hepatic triglycerides after metreleptin. These therefore are strong candidates for therapies to lower triglycerides in these patients.

Keyphrases

end stage renal disease
ejection fraction
newly diagnosed
high density
patient reported outcomes