A new insight into the role of pericytes in ischemic stroke.
Fatemehsadat SeyedaghamiriMohammad Hossein GeranmayehTahereh GhadiriAbbas Ebrahimi-KalanLeila HosseiniPublished in: Acta neurologica Belgica (2023)
The functional structure of the blood-brain barrier (BBB) deteriorates after stroke by developing diffuse microvascular and neurovascular dysfunction and loss of white matter integrity. This causes nervous tissue injury and causes sensory and motor disabilities in stroke patients. Improving the integrity of the BBB and neurovascular remodeling after stroke can promote post-stroke injury conditions. Pericytes are contractile cells abundant in the BBB and sandwiched between astrocytes and endothelial cells of the microvessels. Stroke could lead to the degeneration of pericytes in the BBB. However, recent evidence shows that promoting pericytes enhances BBB integrity and neurovascular remodeling. Furthermore, pericytes achieve multipotent properties under hypoxic conditions, allowing them to transdifferentiate into the brain resident cells such as microglia. Microglia regulate immunity and inflammatory response after stroke. The current review studies recent findings in the intervening mechanisms underlying the regulatory effect of pericytes in BBB recovery after stroke.
Keyphrases
- blood brain barrier
- inflammatory response
- white matter
- induced apoptosis
- cerebral ischemia
- endothelial cells
- cell cycle arrest
- atrial fibrillation
- oxidative stress
- transcription factor
- skeletal muscle
- patient safety
- multiple sclerosis
- toll like receptor
- lps induced
- cell death
- quality improvement
- low grade
- cell proliferation
- smooth muscle
- subarachnoid hemorrhage