Characterizing glucokinase variant mechanisms using a multiplexed abundance assay.

Sarah GersingThea K SchulzeMatteo CagiadaAmelie SteinFrederick P RothKresten Lindorff-LarsenRasmus Hartmann-Petersen

Published in: Genome biology (2024)

In this study, we identify residues important for GCK metabolic stability and conformational dynamics. These residues could be targeted to modulate GCK activity, and thereby affect glucose homeostasis.

Keyphrases

molecular dynamics
high throughput
cancer therapy
molecular dynamics simulations
single cell
blood glucose
metabolic syndrome
drug delivery