Nfib promotes chondrocyte proliferation and inhibits differentiation by mildly regulating Sox9 and its downstream genes.

Daian Pan Benxin Qian Da-Qing Zhao Bao-Jin Yao

Published in: Molecular biology reports (2021)

The molecular mechanism of Nfib in promoting chondrocyte proliferation and inhibiting differentiation was probably achieved by stimulating Sox9 and its downstream genes. Thus, this study adds new insights regarding the underlying molecular mechanism of transcriptional regulation in cartilage.

Keyphrases

signaling pathway
transcription factor
genome wide
stem cells
genome wide identification
bioinformatics analysis
genome wide analysis
gene expression
dna methylation
extracellular matrix