Advances in H 2 O 2 -supplying materials for tumor therapy: synthesis, classification, mechanisms, and applications.

Hydrogen peroxide (H 2 O 2 ) as a reactive oxygen species produced by cellular metabolism can be used in antitumor therapy. However, the concentration of intracellular H 2 O 2 limits its application. Some materials could enhance the concentration of intracellular H 2 O 2 to strengthen antitumor therapy. In this review, the recent advances in H 2 O 2 -supplying materials in terms of promoting intracellular H 2 O 2 production and exogenous H 2 O 2 supply are summarized. Then the mechanism of H 2 O 2 -supplying materials for tumor therapy is discussed from three aspects: reconstruction of the tumor hypoxia microenvironment, enhancement of oxidative stress, and the intrinsic anti-tumor ability of H 2 O 2 -supplying materials. In addition, the application of H 2 O 2 -supplying materials for tumor therapy is discussed. Finally, the future of H 2 O 2 -supplying materials is presented. This review aims to provide a novel idea for the application of H 2 O 2 -supplying materials in tumor therapy.