The anti-migraine component of butterbur extracts, isopetasin, desensitizes peptidergic nociceptors by acting on TRPA1 cation channel.

Silvia BenemeiFrancesco De LoguSimone Li PumaIlaria Maddalena MaroneElisabetta CoppiFilippo UgoliniWolfgang LiedtkeFederica PollastroGiovanni AppendinoPierangelo GeppettiSerena MaterazziRomina Nassini

Published in: British journal of pharmacology (2017)

Activation of TRPA1 channels by isopetasin results in excitation of neuropeptide-containing nociceptors, followed by marked heterologous neuronal desensitization. Such atten uation in pain and neurogenic inflammation may account for the anti-migraine action of butterbur.

Keyphrases

chronic pain
oxidative stress
spinal cord injury
pain management
neuropathic pain
ionic liquid
spinal cord
brain injury
subarachnoid hemorrhage