Bioactive Compounds from the Mushroom-Forming Fungus Chlorophyllum molybdites .

A novel compound ( 1 ) along with two known compounds ( 2 and 3 ) were isolated from the culture broth of Chlorophyllum molybdites , and three known compounds ( 4 - 6 ) were isolated from its fruiting bodies. The planar structure of 1 was determined by the interpretation of spectroscopic data. By comparing the specific rotation of the compound with that of the analog compound, the absolute configuration of 1 was determined to be R . This is the first time that compounds 2 - 4 were isolated from a mushroom-forming fungus. Compound 2 showed significant inhibition activity against Axl and immune checkpoints (PD-L1, PD-L2). In the bioassay to examine growth inhibitory activity against the phytopathogenic bacteria Peptobacterium carotovorum , Clavibacter michiganensis and Burkholderia glumae , compounds 2 and 3 inhibited the growth of P. carotovorum and C. michiganensis. In the bioassay to examine plant growth regulatory activity, compounds 1 - 4 showed a significant regulatory activity on lettuce growth.