Allopurinol hepatotoxicity is associated with human leukocyte antigen Class I alleles.

Robert J FontanaYi-Ju LiElizabeth PhillipsNaba SaeedHuiman BarnhartDavid E KleinerJay Hoofnaglenull null

Published in: Liver international : official journal of the International Association for the Study of the Liver (2021)

Allopurinol hepatotoxicity is associated with systemic hypersensitivity, a short latency to onset, African-American race and three HLA risk alleles, HLA-B*58:01, HLA-B*53:01, and HLA-A*34:02-58:01 testing may help confirm a diagnosis of hepatotoxicity in allopurinol-treated patients.

Keyphrases

african american
drug induced
newly diagnosed
end stage renal disease
ejection fraction
prognostic factors
peripheral blood
induced pluripotent stem cells
patient reported