LncRNA PKMYT1AR promotes cancer stem cell maintenance in non-small cell lung cancer via activating Wnt signaling pathway.

Yaomei HeXiulin JiangLincan DuanQiuxia XiongYixiao YuanPeishen LiuLiping JiangQiushuo ShenSong ZhaoCuiping YangYongbin Chen

Published in: Molecular cancer (2021)

Our findings reveal the critical role of PKMYT1AR/miR-485-5p /PKMYT1 axis during NSCLC progression, which could be used as novel therapeutic targets in the future.

Keyphrases

signaling pathway
cancer stem cells
small cell lung cancer
pi k akt
stem cells
epithelial mesenchymal transition
cell proliferation
genome wide
long non coding rna
current status
induced apoptosis
advanced non small cell lung cancer
single cell
gene expression
oxidative stress