ABCB1 inhibition provides a novel therapeutic target to block TWIST1-induced migration in medulloblastoma.
Aishah NasirAlice CardallRamadhan T OthmanNiovi NicolaouAnbarasu LourdusamyFranziska LinkeDavid OnionMarina RyzhovaHanna CameronCara ValenteAlison RitchieAndrey KorshunovStefan M PfisterAnna M GrabowskaIan D KerrBeth CoylePublished in: Neuro-oncology advances (2021)
In this study, we identified a TWIST1-ABCB1 signaling axis during medulloblastoma migration, which can be therapeutically targeted with the clinically approved ABCB1 inhibitor, vardenafil.