Malignant transformation of oral leukoplakia is associated with macrophage polarization.

Manuel WeberFalk WehrhanChristoph BaranAbbas AgaimyMaike Büttner-HeroldHatice ÖztürkKristina NeubauerClaudia WickenhauserMarco KestingJutta Ries

Published in: Journal of translational medicine (2020)

Immunological changes precede malignant transformation of OLP. Increased macrophage infiltration and M2 polarization was associated with the development of oral cancer in OLP. Macrophage infiltration could serve as predictive marker for malignant transformation.

Keyphrases

adipose tissue