Single-cell exome sequencing reveals multiple subclones in metastatic colorectal carcinoma.

Jie TangKailing TuKeying LuJiaxun ZhangKai LuoHaoxuan JinLei WangLie YangWeiran XiaoQilin ZhangXiaoling LiuXin Yi GeGuibo LiZongguang ZhouDan Xie

Published in: Genome medicine (2021)

In summary, scWES revealed rare mutations that failed to be detected by bulk WES. These rare mutations better define the distinct genomic profiles of primary and metastatic tumour cell clones.

Keyphrases

single cell
rna seq
squamous cell carcinoma
small cell lung cancer
high throughput
copy number
gene expression
bone marrow