Benefit of postoperative regional nodal irradiation in patients receiving preoperative systemic therapy with docetaxel/carboplatin/trastuzumab/pertuzumab for HER2-positive breast cancer.

Nalee KimJi-Yeon KimWon ParkWon Kyung ChoTae Gyu KimYoung-Hyuck ImJin Seok AhnJeong Eon LeeSeok Jin NamSeok Won KimJonghan YuByung Joo ChaeSei Kyung LeeJai-Min RyuYeon Hee ParkHaeyoung Kim

Published in: Breast (Edinburgh, Scotland) (2023)

With a rare incidence of LRR, RNI did not significantly affect LRR or DFS in patients with HER2-positive breast cancer after with PST-TCHP. However, intensive systemic treatment is required for advanced diseases (C/D). Selective de-intensified RNI and intensified systemic treatment should be investigated in future studies.

Keyphrases

positive breast cancer
patients undergoing
epidermal growth factor receptor
clinical trial
risk factors
squamous cell carcinoma
radiation therapy
mass spectrometry
metastatic breast cancer
open label
replacement therapy
smoking cessation
study protocol
phase iii