mTOR hypoactivity leads to trophectoderm cell failure by enhancing lysosomal activation and disrupting the cytoskeleton in preimplantation embryo.

Chiyuan MaQin LiYuxin YangLei GeJiaxuan CaiJuan WangMaoxian ZhuYue XiongWenya ZhangJingtong XieYujing CaoHuashan ZhaoQing WeiChen HuangJunchao ShiJian V ZhangEnkui DuanXiaohua Lei

Published in: Cell & bioscience (2023)

These results demonstrate that mTOR plays a crucial role in 8-cell to blastocyst transition and safeguards embryo quality during early embryo development.

Keyphrases

single cell
cell therapy
cell proliferation
pregnancy outcomes
stem cells
pregnant women
quality improvement
mesenchymal stem cells