Myostatin as a fibroblast-activating factor impacts on postoperative outcome in patients with hepatocellular carcinoma.

Sachiyo YoshioTomonari ShimagakiRyuki HashidaTakumi KawaguchiYuriko TsutsuiYuzuru SakamotoYuichi YoshidaHironari KawaiShiori YoshikawaTaiji YamazoeTaizo MoriYosuke OsawaShinji ItohMoto FukaiTomoharu YoshizumiAkinobu TaketomiMasaki MoriTatsuya Kanto

Published in: Hepatology research : the official journal of the Japan Society of Hepatology (2021)

In patients with NAFLD-HCC without advanced liver fibrosis, high levels of serum myostatin were associated with poor OS. Myostatin activated primary fibroblasts and stimulated collagen production.

Keyphrases

liver fibrosis
patients undergoing
signaling pathway
wound healing
extracellular matrix
tissue engineering