Cathepsin K activity controls cachexia-induced muscle atrophy via the modulation of IRS1 ubiquitination.

Xiangkun MengZhe HuangAiko InoueHailong WangYing WanXueling YueShengnan XuXueying JinGuo-Ping ShiMasafumi KuzuyaXian Wu Cheng

Published in: Journal of cachexia, sarcopenia and muscle (2022)

These results demonstrate that CTSK plays a novel role in IRS1 ubiquitination in LLC-induced muscle wasting, and suggest that CTSK could be an effective therapeutic target for cancer-related cachexia.

Keyphrases

high glucose
diabetic rats
skeletal muscle
drug induced
endothelial cells
oxidative stress