The Proinflammatory Role of ANGPTL8 R59W Variant in Modulating Inflammation through NF-κB Signaling Pathway under TNFα Stimulation.
Mohamed Abu-FarhaDhanya MadhuPrashantha HebbarAnwar MohammadArshad ChannanathSina KavalakattNada Alam-EldinFatima AlterkiIbrahim A TaherOsama AlsmadiMohammad ShehabHossein ArefanianRasheed AhmadThangavel Alphonse ThanarajFahd Al-MullaJehad AbubakerPublished in: Cells (2023)
ANGPTL8 R59W is associated with increased circulatory TNFα, IL7, and NF-κB p65 activity. Weak transient binding of the ANGPTL8 R59W variant explains its regulatory role on the NF-κB pathway and inflammation.