Reduced olfactory bulb volume in depression-A structural moderator analysis.
Fabian RottstädtPengfei HanKerstin WeidnerJulia SchellongSylvia Wolff-StephanTimmy StraußHagen KitzlerThomas HummelIlona CroyPublished in: Human brain mapping (2018)
The OB volume relates to depression in humans and to the volume of structures which are critical for salience detection. We assume that a reduced OB volume causes diminished neural olfactory input which facilitates volume reduction in the insula and STG. The OB volume may hence constitute a factor of vulnerability to depression. Olfactory-based deep brain stimulation is discussed as a future therapeutic approach.