Reflux conditions induce E-cadherin cleavage and EMT via APE1 redox function in oesophageal adenocarcinoma.

Heng LuLong Long CaoFarah BalloutAbbes BelkhiriDunFa PengLei ChenZheng ChenMohammed SouttoTimothy C WangJianwen QueSilvia GiordanoMary Kay WashingtonSteven ChenOliver Gene McDonaldAlexander Zaika Wael El-Rifai

Published in: Gut (2023)

Reflux conditions promote EMT via APE1 redox-dependent E-cadherin cleavage. APE1-redox function inhibitors can have a therapeutic role in EAC.

Keyphrases

epithelial mesenchymal transition
dna binding
squamous cell carcinoma
electron transfer