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Antibody barriers to going viral.

Dennis R Burton
Published in: The Journal of experimental medicine (2019)
Antibody neutralization of a virus in vitro is often associated with protection against viral exposure in vivo, but the mechanisms operational in vivo are often unclear. By investigating a large number of antibodies, Earnest et al. (https://doi.org/10.1084/jem.20190736) show the importance of antibody effector function in neutralizing antibody protection against an emerging alphavirus in a mouse model.
Keyphrases
  • mouse model
  • sars cov
  • dendritic cells
  • immune response
  • zika virus