Cyclin Pathway Genomic Alterations Across 190,247 Solid Tumors: Leveraging Large-Scale Data to Inform Therapeutic Directions.

Denis Leonardo Fontes JardimSherri Z MillisJeffrey S RossMichelle Sue-Ann WooSiraj M AliRazelle Kurzrock

Published in: The oncologist (2020)

Cyclin pathway genomic abnormalities are frequent in human solid tumors, with substantial variation according to tumor site and histology. Opportunities for targeted therapy emerge with comprehensive profiling of this pathway.

Keyphrases

cell cycle
endothelial cells
gene expression
electronic health record
single cell
cell proliferation
big data
cell cycle arrest
induced pluripotent stem cells