Dexmedetomidine or Propofol for Sedation in Mechanically Ventilated Adults with Sepsis.

Christopher G HughesPatrick T MaillouxJohn W DevlinJoshua T SwanRobert D SandersAntonio AnzuetoJames C JacksonAimee S HoskinsBrenda T PunOnur M OrunRameela RamanJoanna L StollingsAmy L KiehlMatthew S DupreyLan N BuiHollis R O'NealAllison SnyderMichael A GropperKalpalatha K GuntupalliGregg J StashenkoMayur B PatelNathan E BrummelTimothy D GirardRobert S DittusGordon R BernardE Wesley ElyPratik P Pandharipandenull null

Published in: The New England journal of medicine (2021)

Among mechanically ventilated adults with sepsis who were being treated with recommended light-sedation approaches, outcomes in patients who received dexmedetomidine did not differ from outcomes in those who received propofol. (Funded by the National Institutes of Health; ClinicalTrials.gov number, NCT01739933.).

Keyphrases

intensive care unit
mechanical ventilation
acute kidney injury
acute respiratory distress syndrome
cardiac surgery
septic shock
healthcare
public health
type diabetes
quality improvement
metabolic syndrome
extracorporeal membrane oxygenation
skeletal muscle
climate change
weight loss