Stereoselective synthesis, X-ray analysis, computational studies and biological evaluation of new thiazole derivatives as potential anticancer agents.
Yahia Nasser MabkhotMohammed M AlharbiSalim S Al-ShowimanHazem A GhabbourNabila A KhederSaied M SolimanWolfgang FreyPublished in: Chemistry Central journal (2018)
Synthesis of novel thiazole derivatives was done. The structure was established using X-ray and spectral analysis. Optimized molecular structures at the B3LYP/6-31G(d,p) level were investigated. Thiazole derivative 11 has more electropositive S-atom than thiazole 6. The HOMO-LUMO energy gap is lower in the former compared to the latter. The synthesized compounds showed moderate anticancer activity.