5,12-Dihydroindolo[3,2-a]Carbazole Derivatives-Based Water Soluble Photoinitiators for 3D Antibacterial Hydrogels Preparation.
Hong ChenTimur BorjiginChristophe RegeardPu XiaoFrédéric DumurJacques LalevéePublished in: Small (Weinheim an der Bergstrasse, Germany) (2023)
Indolo[3,2-a]carbazole alkaloids have drawn a growing interest in recent years owing to their potential electrical and optical properties. With 5,12-dihydroindolo[3,2-a]carbazole serving as the scaffold, two novel carbazole derivatives are synthesized in this study. Both compounds are extremely soluble in water, with solubility surpassing 7% in weight. Intriguingly, the introduction of aromatic substituents contributed to drastically reduce the π-stacking ability of carbazole derivatives, while the presence of the sulfonic acid groups enables the resulting carbazoles remarkably soluble in water, allowing them to be used as especially efficient water-soluble PIs in conjunction with co-initiators, i.e., triethanolamine and the iodonium salt, respectively, employed as electron donor and acceptor. Surprisingly, multi-component photoinitiating systems based on these synthesized carbazole derivatives could be used for the in situ preparation of hydrogels containing silver nanoparticles via laser write procedure with a light emitting diode (LED)@405 nm as light source, and the produced hydrogels display antibacterial activity against Escherichia coli.
Keyphrases
- water soluble
- silver nanoparticles
- light emitting
- escherichia coli
- drug delivery
- tissue engineering
- hyaluronic acid
- extracellular matrix
- structure activity relationship
- wound healing
- body mass index
- photodynamic therapy
- staphylococcus aureus
- quantum dots
- high resolution
- pseudomonas aeruginosa
- weight gain
- biofilm formation
- mass spectrometry
- candida albicans