Genetic Support of A Causal Relationship Between Iron Status and Type 2 Diabetes: A Mendelian Randomization Study.

Xinhui Wang Xuexian FangWanru ZhengJiahui ZhouZijun SongMingqing Xu Junxia Min Fudi Wang

Published in: The Journal of clinical endocrinology and metabolism (2021)

Genetic evidence supports a causal link between increased systemic iron status and increased T2D risk. Further studies involving various ethnic backgrounds based on individual-level data and studies regarding the underlying mechanism are warranted for reducing the risk of T2D.

Keyphrases

type diabetes
genome wide
case control
copy number
iron deficiency
cardiovascular disease
big data
insulin resistance
dna methylation
metabolic syndrome