Treatment of prednisolone-induced hyperglycaemia in hospitalized patients: Insights from a randomized, controlled study.

Anjana RadhakuttyJessica L StranksBrenda L MangelsdorfSophie M DrakeGregory W RobertsAnthony T ZimmermannStephen N StranksCampbell H ThompsonMorton G Burt

Published in: Diabetes, obesity & metabolism (2017)

There were no differences in the efficacy or safety of the isophane and glargine-based insulin regimens. We recommend an initial daily insulin dose of 0.5 units/kg bodyweight if not on insulin, a greater than 30% increase in pre-prednisolone insulin dose and larger insulin dose adjustments in patients with prednisolone-induced hyperglycaemia.

Keyphrases

type diabetes
glycemic control
high glucose
diabetic rats
oxidative stress
endothelial cells
combination therapy