Hyperinflammation Reduces Midazolam Metabolism in Critically Ill Adults with COVID-19.

Tim J L SmeetsAbraham J ValkenburgMathieu van der JagtBirgit C P KochHenrik EndemanDiederik A M P J GommersSebastian D T SassenNicole G M Hunfeld

Published in: Clinical pharmacokinetics (2022)

Inflammation, reflected by high IL-6, reduces midazolam clearance in critically ill patients with COVID-19. This knowledge may help avoid oversedation, but further research is warranted.

Keyphrases

coronavirus disease
sars cov
oxidative stress
healthcare
respiratory syndrome coronavirus