Tamoxifen metabolites treatment promotes ERα+ transition to triple negative phenotype in vitro, effects of LDL in chemoresistance.

Andrea Muñoz-AyalaBrenda Chimal-VegaNicolás Serafín-HigueraOctavio Galindo-HernándezGladys Ramírez-RosalesIván Córdova-GuerreroLuis Fernando Gómez-LucasVictor García-González

Published in: Bioscience reports (2024)

LDL high or low concentrations during Tamoxifen´s metabolites chemoresistance acquisition leads to different cellular mechanisms related to chemoresistance. A novel adaptative cellular response associated with Nrf2 activity could be implicated.

Keyphrases

estrogen receptor
breast cancer cells
ms ms
positive breast cancer
oxidative stress
cancer stem cells