Gastrodin improves nerve cell injury and behaviors of depressed mice through Caspase-3-mediated apoptosis.

Hongyan Pei Heping ShenJinhao BiZhongmei HeLiping Zhai

Published in: CNS neuroscience & therapeutics (2023)

We find that GAS can act as a Caspase-3 inhibitor, which improves depression-like behaviors and nerve cell injury in CUMS mice by inhibiting Caspase-3-mediated apoptosis.

Keyphrases

cell death
single cell
induced apoptosis
cell therapy
high fat diet induced
depressive symptoms
stem cells
peripheral nerve
endoplasmic reticulum stress
oxidative stress
skeletal muscle
sleep quality
physical activity
mesenchymal stem cells
room temperature
insulin resistance
carbon dioxide