Induction of ferroptosis promotes vascular smooth muscle cell phenotypic switching and aggravates neointimal hyperplasia in mice.

Shunchi ZhangYanrou BeiYueling HuangYimin HuangLianjie HouXi-Long ZhengYiming XuShaoguo WuXiaoyan Dai

Published in: Molecular medicine (Cambridge, Mass.) (2022)

Ferroptosis induces VSMC phenotypic switching and accelerates ligation-induced neointimal hyperplasia in mice. Our findings suggest inhibition of ferroptosis as an attractive strategy for limiting vascular restenosis.

Keyphrases

smooth muscle
cell death
high fat diet induced
single cell
high glucose
cell therapy
type diabetes
stem cells
wild type
oxidative stress
mesenchymal stem cells
angiotensin ii