Transcriptional cascades during fasting amplify gluconeogenesis and instigate a secondary wave of ketogenic gene transcription.

Dana GoldbergNufar BuchshtabMeital Charni-NatanIdo Goldstein

Published in: Liver international : official journal of the International Association for the Study of the Liver (2024)

This study reveals abundant transcriptional cascades occurring during fasting. These cascades serve two separated purposes: the amplification of the gluconeogenic transcriptional program and the induction of a gene program aimed at enhancing ketogenesis.

Keyphrases

transcription factor
gene expression
quality improvement
genome wide identification
blood glucose
copy number
genome wide
insulin resistance
heat shock
dna methylation
metabolic syndrome
oxidative stress
nucleic acid
skeletal muscle
weight loss