The size of human subcutaneous adipocytes, but not adiposity, is associated with inflammation, endoplasmic reticulum stress, and insulin resistance markers.
Sara PourdashtiNassim FaridiForouzandeh Monem-HomaieS Hamid YaghootiAhmadreza SoroushS Zahra BathaiePublished in: Molecular biology reports (2023)
The results suggest that the capability of adipogenesis with inadequate angiogenesis is related to the metabolic status, inflammation, and ER function. Therefore, therapeutic strategies that support both angiogenesis and adipogenesis can effectively prevent the complications of obesity.
Keyphrases
- insulin resistance
- high fat diet induced
- endoplasmic reticulum stress
- endothelial cells
- adipose tissue
- oxidative stress
- induced apoptosis
- metabolic syndrome
- high fat diet
- polycystic ovary syndrome
- skeletal muscle
- type diabetes
- vascular endothelial growth factor
- induced pluripotent stem cells
- estrogen receptor
- wound healing
- breast cancer cells
- endoplasmic reticulum