Molecular profiling of soft-tissue sarcomas with FoundationOne® Heme identifies potential targets for sarcoma therapy: a single-centre experience.

Susanne ScheiplIva BrcicTina MoserStefan FischerauerJakob RiedlMarko BergovecMaria SmolleFlorian PoschArmin GergerMartin PichlerHerbert StoegerAndreas LeithnerEllen HeitzerBernadette Liegl-AtzwangerJoanna Szkandera

Published in: Therapeutic advances in medical oncology (2021)

In summary, FoundationOne® Heme detected a broad range of genetic alterations and potential therapeutic targets in STS (e.g. HGF/MET in a subset of MFS, or PIK3CA in MLS). The assay's sensitivity for fusion detection was low in our sample and needs to be re-evaluated in a larger cohort.

Keyphrases

soft tissue
genome wide
single cell
human health
copy number
high throughput
stem cells
tyrosine kinase
high grade
gene expression
bone marrow
single molecule
protein kinase
real time pcr