Deletion of Alox15 improves kidney dysfunction and inhibits fibrosis by increased PGD2 in the kidney.
Naohiro TakahashiHiroaki KikuchiAyaka UsuiTaisuke FurushoTakuya FujimaruTamami FujikiTomoki YanagiYoshiaki MatsuuraKenichi AsanoKouhei YamamotoFumiaki AndoKoichiro SusaShintaro MandaiTakayasu MoriTatemitsu RaiShinichi UchidaMakoto AritaEisei SoharaPublished in: Clinical and experimental nephrology (2021)
Increased PGD2 in Alox15-/- CKD mouse kidneys could inhibit fibrosis, thereby resulting in CKD improvement. Thus, Alox15 inhibition and PGD2 administration may be novel therapeutic targets for CKD.
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