Predicting molecular initiating events using chemical target annotations and gene expression.

Joseph L BundyRichard JudsonAntony J WilliamsChris GrulkeImran ShahLogan J Everett

Published in: BioData mining (2022)

This methodology can offer insight in prioritizing candidate perturbagens of interest for targeted screens. This approach can also help guide the selection of relevant cellular contexts for screening classes of candidate perturbagens using cell line specific model performance.

Keyphrases

gene expression
dna methylation
genome wide
high throughput
cancer therapy
single molecule
drug delivery