Aptamer-Decorated Self-Assembled Aggregation-Induced Emission Organic Dots for Cancer Cell Targeting and Imaging.
Pengfei ZhangZheng ZhaoChuansheng LiHuifang SuYayun WuRyan Tsz Kin KwokJacky Wing Yip LamPing GongLintao CaiBen-Zhong TangPublished in: Analytical chemistry (2017)
A facile and simple one-step method was developed to fabricate aptamer-decorated self-assembled organic dots with aggregation-induced emission (AIE) characteristics. With integration of the advantages of AIE aggregates with strong emission and the cell-targeting capability of aptamers, the as-prepared Apt-AIE organic nanodots can specifically target to cancer cells with good biocompatibility, high image constrast, and photostability. On the basis of this universal method, a variety of versatile organic fluorescent nanoprobes with high brightness, specific recognition, and clinical-transitional potential could be facilely constructed for biological sensing and imaging applications.
Keyphrases
- fluorescent probe
- living cells
- quantum dots
- high resolution
- water soluble
- reduced graphene oxide
- gold nanoparticles
- sensitive detection
- highly efficient
- cancer therapy
- single cell
- label free
- cell therapy
- machine learning
- drug delivery
- mesenchymal stem cells
- single molecule
- climate change
- tissue engineering
- nucleic acid
- metal organic framework