Psychiatric disorders and Type 2 diabetes mellitus: A bidirectional Mendelian randomization.

Haoran TaoShujin FanTianxin ZhuLili YouDinghao ZhengLi YanMeng Ren

Published in: European journal of clinical investigation (2022)

Our studies indicated a causal effect of ADHD and MDD on increasing the risk of T2DM, which was potentially mediated by smoking and obesity-related phenotypes. Meanwhile, we found a causal effect of T2DM on ADHD. Thus, prevention strategies for T2DM should also include mental health and vice versa.

Keyphrases

attention deficit hyperactivity disorder
glycemic control
mental health
autism spectrum disorder
type diabetes
working memory
insulin resistance
weight loss
metabolic syndrome
major depressive disorder
smoking cessation
weight gain
adipose tissue
cardiovascular disease
case control
body mass index
bipolar disorder