Leucine suppresses glucagon secretion from pancreatic islets by directly modulating α -cell cAMP.

Emily R Knuth Hannah R FosterErli JinMatthew J Merrins

Published in: bioRxiv : the preprint server for biology (2023)

Leucine inhibits glucagon secretion from mouse and human isletsLeucine suppresses α-cell cAMP via both direct and paracrine effectsAnaplerosis via glutamate dehydrogenase is sufficient to suppress α-cell cAMPLeucine suppresses α-cell cAMP and glucagon secretion more potently than glucose.

Keyphrases

single cell
cell therapy
signaling pathway
endothelial cells
mesenchymal stem cells
binding protein
protein kinase