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Favorable outcome of retreatment by direct-acting antivirals for hepatitis C patients with daclatasvir plus asunaprevir combination therapy failure.

Hiroki TojimaSatoru KakizakiSatoshi TakakusagiTakashi HoshinoAtsushi NaganumaTamon NagashimaMasashi NamikawaTakashi UenoYasushi ShimadaTakeshi HatanakaDaichi TakizawaHirotaka AraiKen SatoHitoshi TakagiToshio Uraoka
Published in: Hepatology research : the official journal of the Japan Society of Hepatology (2019)
Amino acid substitutions were frequently observed in patients with DCV + ASV failure, but most patients achieved a sustained virological response after retreatment with DAAs. Although the spread of drug-resistant viruses due to unsuccessful DAA treatment was a matter of concern, most cases of DCV + ASV failure were overcome with additional treatment.
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